What to Expect in Your First Week on GLP-1s
- The Editor
- Jun 17
- 5 min read
Disclaimer: The content provided by Jurni GLP is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Individual experiences with GLP-1 medications may vary. Always consult a qualified healthcare provider before making any medical decisions or starting any new treatment.
Starting GLP-1 medications like Ozempic®, Wegovy®, Mounjaro®, or Zepbound® is more than just picking up a prescription—it’s a commitment to reclaiming control over your health and wellness. Whether you’re embarking on this journey to better manage your weight, regulate blood sugar levels, or improve overall metabolic health, the first week with GLP-1s is an adventure into the unknown. Change can feel both exciting and daunting, which is why knowing what’s ahead can make the process smoother and more empowering.
Most importantly, you’re not alone. At Jurni GLP, we’re here to help you through every step of your GLP-1 experience, starting with this crucial opening week. This guide will unpack each stage, offering practical tips, motivational insights, and actionable advice that will leave you saying, “This is exactly what I needed.”
Day 1: Your First Dose
Taking your first dose feels monumental—it’s the start of something transformative. The first day, however, can bring a mix of emotions, from excitement to nerves. Rest assured, this is your time to ease into the routine.
What to Expect
Subtle Start: Many don’t experience significant side effects on Day 1. GLP-1s take time to build in your system and interact with your body’s appetite and insulin mechanisms.
Mild Fatigue: You might feel a little tired, as your body begins adapting to the new medication.
Pro Tips for Day 1:
Stay Hydrated: Drinking plenty of water helps your body adjust smoothly. It can also prevent potential headaches or fatigue caused by dehydration.
Set a Routine: Choose a time for your weekly injections that fits seamlessly into your schedule—it’s easier to stick with consistency this way.
Get Comfortable: If you’re feeling anxious about injecting, try icing the area before insertion or practicing calming breathwork to ease tension.
Wondering what to use or where to start? Consider having a sharps container or alcohol swabs on hand for safe and smooth injections. You can grab these from sites like Amazon or your local pharmacy.
Days 2-3: Subtle Shifts Begin
By Day 2, you may start feeling early, delicate shifts as GLP-1 begins working inside your body. This is when GLP-1 starts interacting with hunger-regulating hormones and insulin production.
What to Expect:
Slight Appetite Changes: You may feel fuller a little faster or have fewer intrusive cravings, but the changes will be gentle.
Possible Nausea: The most common side effect reported during the first week is nausea due to the slowdown in digestion—a normal part of how GLP-1s work to control appetite.
Tips to Stay Ahead of Nausea:
Eat Small, Balanced Meals: Avoid greasy, fried, or heavy foods. Instead, focus on lean proteins, fresh vegetables, and fiber-rich carbs that digest with ease.
Ginger to the Rescue: Ginger tea or candies can soothe your stomach naturally. Peppermint is another helpful remedy for queasy days.
Sit Upright After Eating: This simple habit can aid digestion and reduce discomfort.
These minor adjustments are temporary, and for most people, they diminish as their bodies settle into the medication.
Days 4-5: Appetite Changes Take Hold
By midweek, you’ll likely notice the real appetite suppression kicking into gear. Many people report feeling full with much smaller portions, and some habits—like snacking or overeating—begin to feel less automatic.
What to Expect:
Stronger Hunger Control: You may feel more satisfied from smaller meals. This stronger sense of satiety makes it easier to stick to healthier portion sizes.
Focus on Hydration: GLP-1s may increase thirst, so hydration becomes even more critical.
Pro Tips for Days 4-5:
Plan High-Energy Meals: Protein-rich meals with healthy fats (e.g., salmon, avocado) keep you full while maximizing energy.
Carry a Water Bottle Everywhere: Staying hydrated not only combats thirst but can also stave off headaches or mild fatigue. Pairing water with low-sodium electrolyte tablets boosts hydration further.
Listen to Your Body: Avoid eating out of habit or emotional triggers; aim to tune into your true hunger cues—this process is as mental as it is physical.
Day 6: Reflecting on Progress
Your sixth day is a perfect point for an emotional and physical check-in. You might notice that tasks like preparing meals or resisting certain cravings feel easier. Many people also experience initial weight changes.
What to Reflect On:
Physical Progress: Clothes feeling looser? Noticing fewer highs and lows in energy? These wins, while subtle, signify that your body is adapting.
Mental Shifts: Feeling a little bit prouder of your food choices? Remember that, while the medication is a tool, these actions are driven by you.
Tips for Day 6:
Celebrate Non-Scale Victories: Weight change is just part of the process; things like reduced cravings, improved mood, or cooking more meals matter, too.
Capture the Moment: Write down how you feel or snap a picture. Documenting small wins makes long-term changes easier to review—and celebrate!
Maintaining realistic expectations is key. Rapid progress isn’t the norm; rather, gradual success builds lasting change.
Day 7: Your First Full Week—a Milestone
You did it! Completing your first week on GLP-1s is a major accomplishment and sets the tone for weeks to come. For many, this week highlights their ability to adapt and stay consistent—not just with medication but with healthier habits.
What to Expect:
Feeling Empowered: With reduced side effects and noticeable progress (however small), confidence in your decision may grow.
More Stable Energy Levels: You might be experiencing steadier energy throughout the day, especially compared to the start of your week.
Next Steps for Success:
Set Mini Goals: Progress might look different in Week Two and beyond. Start small, whether it’s adding an extra 5-minute walk to your day or trying one new healthy recipe.
Join a Supportive Group: Connecting with others using GLP-1 medications—like online communities or Jurni GLP’s resources—can be motivating.
Prepare for Appointments: If you have a follow-up with your healthcare provider, jot down any lingering questions or observations to guide the conversation.
This is only the beginning of a longer, rewarding transformation. Take a moment to celebrate how far you’ve already come.
Common Questions About Week One
1. When Will Side Effects Subside?
For most people, side effects like nausea or fatigue diminish significantly within the first 1-2 weeks. If they persist or worsen, consult your healthcare provider. They may adjust your dose or offer practical remedies.
2. What If This Week Didn’t Go Perfectly?
No health journey is flawless. Focus on small wins and don’t dwell on perceived mistakes. Progress builds with patience, not perfection.
3. Can I Start Seeing Results in Week One?
Many don’t notice significant weight changes this early—what’s more important is the foundation of healthy habits you’re building. Appetite control is an essential first step.
The Takeaway
Your first week on GLP-1s is all about adjustments—not just for your body, but for your mindset, too. Every accomplishment, no matter how small, contributes to a solid foundation for long-term health. With guidance, consistency, and a little patience, the rewards of this wellness journey will far outweigh any rocky start.
Jurni GLP is here to help every step of the way. From articles like this to community connections, we’re proud to support you toward sustaining a healthier, happier lifestyle.
Disclaimer: The content provided by Jurni GLP is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Individual experiences with GLP-1 medications may vary. Always consult a qualified healthcare provider before making any medical decisions or starting any new treatment.
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